مقایسه اثربخشی گیاه جینکوبیلوبا (Ginkgo biloba L.) با داروی سیناریزین بر شدّت وزوز گوش بیماران مبتلا به وزوز گوش ذهنی

Background and Aim: Subjective Tinnitus is one of the common problems in the world whose prevalence is estimated to be 7-20 percent in the community. In the present study, effectiveness of Ginkgo biloba with that of cinnarizine on subjective tinnitus were compared and assessed in order to determine the effective dose of Ginko on .patients. Materials and Methods: This clinical trial study conducted on 61 patients with subjective tinnitus who had been referred or had come to Shahrekord ENT clinic .The patients who did not have certain pathologic physical problems .were randomly divided into two groups (Cinnarizine & Ginko biloba).The patients filled out .Tinnitus Severity Index (TSI) form and after 2 months they were assessed. The obtained data was analyzed by means of SPSS software (V: 17) using chi-square, paired t test, and independent T test. Results: According to the findings in Ginkgo Biloba group the two criteria the severity of tinnitus and the .adverse changes in quality of life significantly reduced after treatment (P=0.001, P=0.006), respectively. In Cinnarizine group, both criterion reduced after treatment, but just the severity of tinnitus decreased significantly (P=0.006). The overall response to treatment in Ginkgo Biloba group was significantly higher than Cinnarizine group, but the difference was not significant (P>0.05). Conclusion: It was found that after two months of treatment with Ginkgo biloba (120-140 mg daily) tinnitus severity and the adverse changes on quality of life significantly decreased in the patients, whereas Cinnarizine did not reduce the latter significantly. However, no significant difference was observed between the two groups (Cinnarizine & Ginko biloba).